GROWTH FACTORS:
THE SCIENCE BEHIND SKIN REJUVENATION.
Rahul C. Mehta, PhD, VP Research &
Development, SkinMedica®, An Allergan Company
Growth factors play a pivotal role in maintaining firmness and elasticity in your skin. Daily use of skin care products
containing growth factors are known to help reduce the appearance of fine lines, wrinkles and improve skin tone and texture.
But, not all products containing growth factors have the same benefits. Dr. Rahul Mehta, Head of Research and Development
at SkinMedica® (a pioneer in using growth factors in cosmetic treatments), explains why growth factors are imperative for
skin rejuvenation.
What are Growth Factors and why do we need them in skin care products?
Growth factors are natural substances made by skin cells to maintain healthy skin. They are
responsible for supporting the repair of damaged skin, making components that provide firmness
and elasticity to the skin while helping to maintain skin’s protective functions. They are NOT Growth
Hormones! Aging and sun-damaged skin require growth factors to maintain itself. However cells in
aging skin make less growth factors than cells in youthful skin. One approach to support the levels
of skin rejuvenation is to regularly use skin care products with a high concentration of stable
growth factors.
Where do Growth Factors in skin care products come from?
Advances in biotechnology over the past decade have created multiple sources of growth factors.
They can be derived from several different human cells grown in a laboratory (skin cells, bone
marrow stem cells, fat stem cells), extracted from one’s own blood (PRP - Platelet Rich Plasma) or
from non-human sources such as snails and some plants. While all cells can produce growth
factors, the composition of the growth factor blend they produce is likely to be ideal for the health
of cells that produce them. For example, fat stem cells are likely to produce growth factors that
help the functioning of fat cells and bone marrow stem cells are likely to produce growth factors
that help with functioning of bone marrow. Similar logic can be applied to growth factors or
growth factor-like substances derived from non-human sources. Therefore, to maintain optimal skin
health, ideal growth factors would be produced by skin cells, called fibroblasts, whose main
function is to produce the components necessary to support the skin.
Do Growth Factors really work?
Several clinical studies, over the past 15 years, have highlighted the benefits of topically applied
growth factor products showing improvements in the appearance of fine lines, wrinkles, texture,
and discoloration. The studies show that, depending on the quality of skin, good results take 6-12
weeks of twice a day use. The diligence is definitely worth it as the improvement in skin
appearance is very impressive! Most studies show visible reduction in crow’s feet lines, under-eye
skin texture, and overall radiance. Combinations of growth factors with strong antioxidants tend to
show results sooner, typically within 4-8 weeks. TNS Essential Serum® provides a combination of
stable growth factors (TNS Recovery Complex®) with strong antioxidants (APS Corrective
ComplexTM) designed to provide this rapid effect. Over 11 clinical studies have been conducted
looking at cosmetic efficacy with TNS Essential Serum® with results showcasing its ability to
improve the overall appearance of skin. These are more studies than any other topical cosmetic
growth factor product in the market today.
Who should use Growth Factor Products?
Clinical results show that growth factor products
benefit anyone with visible signs of facial aging.
While women with early signs of aging may benefit
by using growth factors, most significant visible
improvements in skin are seen in women with
greater photodamage and mature skin. Twice a day
use with diligence is the key to maximizing benefits
from growth factors products. Your skin care
professional can advise whether or not products
containing growth factors are right for you.
How does TNS Essential Serum® stand out from other Growth Factor products
on the market?
TNS Recovery Complex® is the first topical cosmetic made almost entirely of stabilized human
growth factor (93.6%). The growth factors are harvested using a patented process that ensures
their stability and activity. Furthermore, TNS Recovery Complex® formulation and manufacturing
process maintains the stability of active growth factors. Multiple published studies in scientific
journals and conferences have verified the presence of active growth factors in TNS Recovery
Complex®. Carefully selected antioxidants and peptides present in TNS Essential Serum®
complement the benefits of growth factors.
What other products should I use with
Growth Factors?
A good skin care regimen requires regular use of an
SPF 30 or higher broad-spectrum sunscreen.
Protecting newly rejuvenated skin is essential in
maintaining results. Free radicals produced by sun
exposure, smoking, and pollution can damage skin
rapidly, negating any benefits of growth factors.
Antioxidants, such as Vitamin C, neutralize free
radicals and provide an extra layer of protection
beyond sunscreen alone. Total Defense + Repair
provides protection from sun exposure and free
radicals. For more serious skin concerns, Vitamin A
(retinol) may be added to the regimen with growth
factor products. Retinol works slightly differently
than growth factors so the combination would
provide a better outcome than either one alone. Talk
to your skin care provider about a complete
regimen that is right for you.
Rahul C. Mehta, PhD is Vice President of
Research & Development for SkinMedica®. He is
a pharmacist by training with over 30 years of
experience in pharmaceutical research and
development. He has authored or co-authored
over 50 research publications and book
chapters, over 150 poster presentations and
multiple patents in pharmaceutical sciences. Dr.
Mehta is strongly committed to bringing
pharmaceutical level evidence-based skin care
with strong biology and clinical science for
creation of multi-modality holistic
skin care produc